Mac and Cheese Meatloaf Casserole

Mac and Cheese Meatloaf Casserole is a delicious fusion of two classic comfort foods—savory meatloaf and creamy macaroni and cheese. This hearty and satisfying dish brings together juicy, flavorful meatloaf with a rich, cheesy pasta layer, creating a meal that is both nostalgic and innovative.

Perfect for family dinners, potlucks, or meal prepping, this casserole combines the best of both worlds into a convenient, crowd-pleasing dish. Whether you’re making it for a weeknight meal or a special gathering, this recipe guarantees comfort and flavor in every bite.

Ingredients Breakdown

• For the Meatloaf Base:
• 2 pounds lean ground beef – The hearty protein base of the dish.
• 1 sleeve Ritz Crackers, crushed – Adds a buttery texture and acts as a binder.
• 1 packet Lipton onion soup mix – Infuses deep, savory flavor into the meatloaf.
• 2 large eggs – Helps hold the meatloaf together and maintain moisture.
• ½ cup ketchup – Brings a tangy, slightly sweet element to balance the meat.
• ½ cup Sweet Baby Ray’s barbecue sauce – Provides a rich, smoky-sweet glaze.

• For the Mac and Cheese Layer:
• 2 cups elbow macaroni – The pasta base that absorbs all the creamy goodness.
• 1 cup whole milk – Helps create a smooth, creamy cheese sauce.
• 1 (10.5 oz) can condensed cheddar cheese soup – Enhances creaminess and flavor.
• ½ teaspoon salt – Brings out the flavors in the cheese sauce.
• ½ teaspoon black pepper – Adds mild spice and depth.
• ½ teaspoon garlic powder – Infuses a subtle garlicky flavor.
• ½ teaspoon onion powder – Complements the richness of the cheese sauce.
• 1 ½ cups shredded mozzarella and cheddar cheese blend, divided – Provides a gooey, melty texture.

Step-by-Step Preparation

Step 1: Prepare the Meatloaf Base

Preheat the oven to 350°F (175°C) and grease a 9×13-inch baking dish.

In a large mixing bowl, combine the ground beef, crushed Ritz Crackers, Lipton onion soup mix, and eggs.

In a small bowl, mix together ketchup and barbecue sauce.

Divide the sauce mixture in half—one portion will go into the meat mixture, while the other will be used as a glaze.

Press the meat mixture evenly into the prepared baking dish, creating a flat, compact layer.

Spread the remaining barbecue sauce mixture over the top of the meatloaf.

Bake for 30 minutes to allow the meatloaf to firm up before adding the mac and cheese layer.

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Step 2: Cook the Macaroni and Cheese

While the meatloaf is baking, bring a large pot of salted water to a boil.

Cook the macaroni noodles according to package instructions until al dente (firm to the bite).

Drain the pasta and set it aside.

In a large mixing bowl, whisk together the milk and condensed cheddar cheese soup until smooth.

Add the salt, black pepper, garlic powder, and onion powder to the cheese sauce and stir to combine.

Mix in the cooked macaroni, ensuring each piece is coated in the creamy sauce.

Stir in ½ of the shredded mozzarella and cheddar cheese blend.

Step 3: Assemble the Casserole

Once the meatloaf has baked for 30 minutes, remove it from the oven.

Spread the prepared mac and cheese mixture evenly over the meatloaf.

Sprinkle the remaining shredded cheese on top.

Return the dish to the oven and bake for 17–20 minutes, or until the cheese is melted and slightly golden.

Step 4: Serve & Enjoy

Remove from the oven and let the casserole rest for 5–10 minutes before slicing.

Garnish with fresh chopped parsley or a sprinkle of paprika for extra flavor and color.

Serve warm and enjoy the cheesy, meaty, comfort-packed dish!

Tips for Perfect Results

• ✔ Thoroughly mix the meatloaf ingredients to ensure even distribution of flavors and moisture.
• ✔ Cook the macaroni al dente to prevent it from becoming mushy while baking.
• ✔ Use freshly shredded cheese for the best meltability, as pre-shredded cheese contains anti-caking agents.
• ✔ Customize seasonings by adding red pepper flakes, smoked paprika, or a dash of Worcestershire sauce for extra depth.

Serving Suggestions

• 🥗 Crisp Green Salad – Balances the richness of the casserole with fresh, light flavors.
• 🥦 Roasted Vegetables – Broccoli, green beans, or carrots add color and nutrients.
• 🥖 Garlic Bread or Dinner Rolls – Perfect for scooping up the cheesy sauce.
• 🥬 Coleslaw – Provides a cool, crunchy contrast to the warm, creamy dish.

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Variations and Substitutions

• 🔥 Alternative Meats: Try ground turkey, chicken, or a mix of beef and pork for extra richness.
• 🧀 Different Cheese Options: Use Gruyère, Gouda, or Parmesan for a different cheesy twist.
• 🌱 Vegetarian Adaptations: Replace meat with lentils, chickpeas, or finely chopped mushrooms.

Storage & Reheating Instructions

• ✔ Refrigerate: Store in an airtight container for up to 3 days.
• ✔ Freeze: Wrap tightly in foil and freeze for up to 3 months.
• ✔ Reheat:
• Oven: Cover with foil and bake at 350°F for 20–25 minutes.
• Microwave: Heat in 30-second intervals, stirring occasionally.

Final Thoughts

Mac and Cheese Meatloaf Casserole is a flavor-packed comfort dish that blends two classic favorites into one delicious meal. Whether you are feeding a hungry family, meal prepping for the week, or bringing a dish to a potluck, this casserole is sure to be a hit.

🔥 Try this creamy, cheesy, and meaty recipe today and enjoy the ultimate comfort food experience! 🍽️✨

Frequently Asked Questions

→ Can I make this casserole ahead of time?

Yes! Assemble the casserole and refrigerate overnight. Bake when ready, adding a few extra minutes if needed.

→ Can I use a different type of cheese?

Absolutely! Try Gruyère, Gouda, or Monterey Jack for a unique twist.

→ How do I store leftovers?

Store in an airtight container in the fridge for up to 3 days. Reheat in the oven at 350°F or microwave individual portions.

→ Can I freeze this casserole?

Yes! Let it cool completely, then freeze in portions for up to 3 months. Thaw and reheat before serving.

→ What side dishes go well with this casserole?

Pair it with a crisp green salad, steamed vegetables, or garlic bread.